Article - mitosis-specific regulation of nuclear transport by the spindle ...
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By lv cairo · 2013 · cited by 49 — because npcs are impermeable to most macromolecules, transport is facilitated by a group of proteins, termed nuclear transport factors (ntfs), that traverse the ...
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MolecularCellArticleMitosis-SpecificRegulationofNuclearTransportbytheSpindleAssemblyCheckpointProteinMad1pLucasV.Cairo,1,2ChristopherPtak,1,2andRichardW.Wozniak1,*1DepartmentofCellBiology,UniversityofAlberta,Edmonton,AlbertaT6G2H7,Canada2Theseauthorscontributedequallytothiswork*Correspondence:[email protected]://dx.doi.org/10.1016/j.molcel.2012.10.017SUMMARYNuclearporecomplexes(NPCs)andkinetochoresperformdistincttasks,yettheirsharedabilitytobindseveralproteinssuggeststheirfunctionsarein-tertwined.AmongthesesharedproteinsisMad1p,acomponentoftheyeastspindleassemblycheck-point(SAC).HerewedescribearoleforMad1pinregulatingnuclearimportthatemploysitsabilitytosenseadisruptionofkinetochore-microtubuleinter-actionsduringmitosis.Weshowthatkinetochore-microtubuledetachmentarrestsnuclearimportmediatedbythetransportfactorKap121pthroughamechanismthatrequiresMad1pcyclingbetweenunattached,metaphasekinetochoresandbindingsitesattheNPC.ThissignalingpathwayrequirestheAuroraB-likekinaseIpl1p,andt...
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