Fat2 polarizes the wave complex in trans to align cell protrusions for ...
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By am williams · 2022 · cited by 1 — s3a-d; movie 2); however, f-actin labeling showed a larger disparity ... pressing abi-mcherry and endogenous full-length fat2-3xgfp or ...
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Fat2polarizestheWAVEcomplexintranstoalign1cellprotrusionsforcollectivemigration2AudreyM.Williams1,SethDonoughe1,EdwinMunro1,2,3,SallyHorne-Badovinac1,2,∗34Abstract5Foragroupofcellstomigratetogether,eachcellmustcouplethepolarityofitsmigratorymachinerywiththat6oftheothercellsinthecohort.Althoughcollectivecellmigrationsarecommoninanimaldevelopment,littleis7knownabouthowprotrusionsarecoherentlypolarizedamonggroupsofmigratingepithelialcells.Weaddress8thisprobleminthecollectivemigrationofthefollicularepithelialcellsinDrosophilamelanogaster.Inthisepithe-9lium,thecadherinFat2localizestothetrailingedgeofeachcellandpromotestheformationoflamellipodiaat10theleadingedgeofthecellbehind.WeshowthatFat2performsthisfunctionbyactingintranstorestrictWAVE11complexactivitytoonelong-livedregionalongeachcell’sleadingedge.WithoutFat2,theWAVEcomplexdistri-12butionexpandsaroundthecellperimeterandfluctuatesovertime,resultinginreduced,unpolarizedprotrusive13activity.WefurthershowthatFat2’sinfluenceisverylocal,with...
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