Gfap splice variants fine‑tune glioma cell invasion and tumour dynamics ...
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By r uceda-castro · 2022 · cited by 5 — (b) representative still images from a time-lapse movie showing migratory tumour cells in different gfap. -modulated tumours (ctl1, gfapδ-ko2, gfapα-ko2). red ...
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1Vol.:(0123456789)Scientific Reports | (2022) 12:424 | https://doi.org/10.1038/s41598-021-04127-5www.nature.com/scientificreportsGFAP splice variants fine‑tune glioma cell invasion and tumour dynamics by modulating migration persistenceRebeca Uceda‑Castro1,4, Jessy V. van Asperen2,4, Claire Vennin1, Jacqueline A. Sluijs2, Emma J. van Bodegraven2, Andreia S. Margarido1, Pierre A. J. Robe3, Jacco van Rheenen1,5* & Elly M. Hol2,5*Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocyte‑ and neural stem cell‑derived gliomas. Glioma malignancy is associated with changes in GFAP alternative splicing, as the canonical isoform GFAPα is downregulated in higher‑grade tumours, leading to increased dominance of th...
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