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Pospich et al. eLife 2021;10:e73724. DOI: https://doi.org/10.7554/eLife.73724 1 of 40High- resolution structures of the actomyosin- V complex in three nucleotide states provide insights into the force generation mechanismSabrina Pospich1, H Lee Sweeney2, Anne Houdusse3, Stefan Raunser1*1Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany; 2Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida, Gainesville, United States; 3Structural Motility, Institut Curie, Centre National de la Recherche Scientifique, Paris, FranceAbstract The molecular motor myosin undergoes a series of major structural transitions during its force- producing motor cycle. The underlying mechanism and its coupling to ATP hydrolysis and actin binding are only partially understood, mostly due to sparse structural data on actin- bound states of myosin. Here, we report 26 high- resolution cryo- EM structures of the actomyosin- V com...